shotgun sequencing

English

Etymology

Formed through analogy with the effect of a shotgun blast, which contains many small pellets.

Noun

shotgun sequencing (uncountable)

1. (genetics) A DNA sequencing technique in which a large number of small fragments of a long DNA strand are generated at random, sequenced, and reassembled to form a sequence of the original strand.

   Synonym: shotgun cloning

   • 2005, Selene K Swanson with Michael P. Washburn, “The continuing evolution of shotgun proteomics”, in Drug Discovery Today, →DOI, page 719:

     In shotgun sequencing of genomic DNA, fragments of a genome are sequenced and computationally reassembled to determine the genome of an organism

Translations

DNA sequencing technique

• Chinese: 鸟枪法 (niǎoqiāngfǎ)
• Korean: 샷건 시퀀싱 (syatgeon sikwonsing)

Further reading

• shotgun sequencing on Wikipedia.Wikipedia